Changes in Sarcoma 180 Cells Associated with Drug-induced Resistance to Adenosine Analogs1
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چکیده
pentenyl)adenosine (IPAR). The resistance was unaltered after 5 months maintenance in absence of the drug. S-180/KR cells showed increased sensitivity to certain purine and pyrimidine nucleoside analogs such as 6-thiopurine ribonucleoside and 5-fluorodeoxyuridine. The activity of purine nucleoside phosphorylase (purine nucleoside:orthophosphate ribosyltransferase, EC 2.4.2.1) an enzyme that in crude cell extracts but not in whole cells cleaved IPAR-8-'4C to the noncytotoxic free base at 10% the
منابع مشابه
Changes in sarcoma 180 cells associated with drug-induced resistance to adenosine analogs.
pentenyl)adenosine (IPAR). The resistance was unaltered after 5 months maintenance in absence of the drug. S-180/KR cells showed increased sensitivity to certain purine and pyrimidine nucleoside analogs such as 6-thiopurine ribonucleoside and 5-fluorodeoxyuridine. The activity of purine nucleoside phosphorylase (purine nucleoside:orthophosphate ribosyltransferase, EC 2.4.2.1) an enzyme that in ...
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تاریخ انتشار 2006